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Dany Welmann

Bio statement Braun-Falco: Headed by Prof. Dr. med. E. Christophers, Kiel, and Dr. med. M. Ständer, Bad Bentheim, the 7th Psoriasis Fachtagung took place, very successful. The lectures of the scientific program dealing with the topics "Psoriasis Genes - Psoriasis Types - seborrheic keratosis treatment Therapy" were consistently of international quality. It was astonishing how one day the organizers were able to give an overview of the modern development of genetics, pathogenesis and therapy of psoriasis. Also interesting are the "pro and contra" discussions: UVB versus PUVA, systemic versus topical therapy, and monotherapy versus combination therapy.

The first part was devoted to the preconditions of psoriasis and illuminated their genetics. Thus it could be established that not a monogenetic disease is present, but very probably several genes play a causative role in the psoriasis realization. There are first genome examinations and genetic researches of biochemical nature, which suggest that promising news is still to be expected. One is looking for the psoriasis genes.

Also interesting are the references to the HLA system, which are based, in particular, on the analytical work of Christophers and Henseler, Kiel, and which have shown that we can now distinguish between two types of psoriasis type 1 and type 2. The determination of the HLA pattern has continued seborrheic dermatitis and hair loss. We now know that certain HLA-haplo types are linked to type 1, others are type 2: type 1 is HLA molecules CW 6, B 13 and Bw 57, type 2 B 27, Cw 2 and other.

What is important is that we know more about the genetic backround and have gained more insights into the risk of individual members in vulnerable families through these very broad statistical analyzes.

Can it be foreseen how likely siblings or future children are suffering from psoriasis in an affected family? Braun-Falco: An individual prognosis is not possible. We are also clear on the basis of broad statistical investigations that one can not estimate that the child is at risk for the children - say, 25% and 50% for both parents. We can, however, predict more accurately than before: if a sibling is suffering from psoriasis, the other also has a certain degree of risk.

We have penetrated deeper into the genetics and molecular genetics of psoriasis. Sure, we are also approaching a more accurate assessment of the risk of risk. The latter is, of course, only statistically significant in a larger collective. For the individual case, nothing definitive can be predicted, especially since provocation factors can have seborrheic dermatitis and hair loss very different effects. The program also included contributions on mechanisms of action, immunological factors, triggers. How is research going on in this regard?


The IEECA Press

ISSN 2328-8272 (print)   ISSN 2328-8280 (online)